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学者姓名:王嗣岑

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< Page ,Total 16 >
Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform SCIE
期刊论文 | 2018 , 54 (95) , 13427-13430 | CHEMICAL COMMUNICATIONS
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Abstract :

We report a novel biomimetic drug discovery platform using high expression epidermal growth factor receptor (EGFR) HEK 293 cell membrane camouflaged magnetic nanoparticles. The EGFR/magnetic cell membrane nanoparticles (MCMNs) integrated desirable magnetic features and special binding bioaffinity. Application of this drug-targeting concept is expected to pave ways to a new drug discovery strategy.

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GB/T 7714 Bu, Yusi , Hu, Qi , Ke, Ruifang et al. Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform [J]. | CHEMICAL COMMUNICATIONS , 2018 , 54 (95) : 13427-13430 .
MLA Bu, Yusi et al. "Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform" . | CHEMICAL COMMUNICATIONS 54 . 95 (2018) : 13427-13430 .
APA Bu, Yusi , Hu, Qi , Ke, Ruifang , Sui, Yue , Xie, Xiaoyu , Wang, Sicen . Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform . | CHEMICAL COMMUNICATIONS , 2018 , 54 (95) , 13427-13430 .
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The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR SCIE PubMed Scopus
期刊论文 | 2018 , 8 | SCIENTIFIC REPORTS
WoS CC Cited Count: 1
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Coptidis Rhizoma binds to the membrane receptors on hPDLSC/CMC, and the active ingredient Berberine (BER) that can be extracted from it may promote the proliferation and osteogenesis of periodontal ligament stem cells (hPDLSC). The membrane receptor that binds with BER on the cell surface of hPDLSC, the mechanism of direct interaction between BER and hPDLSC, and the related signal pathway are not yet clear. In this research, EGFR was screened as the affinity membrane receptor between BER and hPDLSC, through retention on CMC, competition with BER and by using a molecular docking simulation score. At the same time, the MAPK PCR Array was selected to screen the target genes that changed when hPDLSC was simulated by BER. In conclusion, BER may bind to EGFR on the cell membrane of hPDLSC so the intracellular ERK signalling pathways activate, and nuclear-related genes of FOS change, resulting in the effect of osteogenesis on PDLSC.

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GB/T 7714 Liu, Jin , Zhao, Xiaodan , Pei, Dandan et al. The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR [J]. | SCIENTIFIC REPORTS , 2018 , 8 .
MLA Liu, Jin et al. "The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR" . | SCIENTIFIC REPORTS 8 (2018) .
APA Liu, Jin , Zhao, Xiaodan , Pei, Dandan , Sun, Guo , Li, Ye , Zhu, Chunhui et al. The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR . | SCIENTIFIC REPORTS , 2018 , 8 .
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Stepwise frontal affinity chromatography model for drug and protein interaction EI SCIE PubMed Scopus
期刊论文 | 2018 , 410 (23) , 5807-5815 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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Frontal affinity chromatography is an efficient technique that combines affinity interaction and high-performance liquid chromatography, and frontal analysis has been used in studying the interaction between drugs and proteins. Based on frontal analysis, stepwise frontal analysis has been established. The present study aimed to use the Lineweaver-Burk plot in stepwise frontal analysis by taking the weighted average of time data. Commercial human serum albumin (HSA) and alpha-1-acid glycoprotein (AGP) columns were used as an affinity column. Warfarin and digitoxin were chosen as model drugs for the HSA column, whereas verapamil and tamsulosin were selected as model drugs for the AGP column. The time data obtained by frontal analysis and stepwise frontal analysiswere compared, and the results revealed good correlation (r2 = 0.9946-0.9998). Frontal analysis and stepwise frontal analysis were also used to analyze the equilibrium dissociation constants (Kd) of model drugs on the HSA and AGP columns. The Kd values were compared with literature values, which revealed the same order of magnitude. These results illustrate that conversion of the time data is reasonable and feasible. The Lineweaver-Burk plot can be used in the stepwise frontal analysis model to study the characteristics of the interaction between drugs and proteins.

Keyword :

Stepwise frontal analysis model Affinity chromatography Equilibrium dissociation constants (K-d) Lineweaver-Burk plot

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GB/T 7714 He, Xiaoshuang , Sui, Yue , Wang, Sicen . Stepwise frontal affinity chromatography model for drug and protein interaction [J]. | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2018 , 410 (23) : 5807-5815 .
MLA He, Xiaoshuang et al. "Stepwise frontal affinity chromatography model for drug and protein interaction" . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY 410 . 23 (2018) : 5807-5815 .
APA He, Xiaoshuang , Sui, Yue , Wang, Sicen . Stepwise frontal affinity chromatography model for drug and protein interaction . | ANALYTICAL AND BIOANALYTICAL CHEMISTRY , 2018 , 410 (23) , 5807-5815 .
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Simultaneous identification and characterization of amanita toxins using liquid chromatography-photodiode array detection-ion trap and time-offlight mass spectrometry and its applications SCIE PubMed Scopus
期刊论文 | 2018 , 296 , 95-104 | TOXICOLOGY LETTERS
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Rapid and accurate identification of multiple toxins for clinical diagnosis and treatment of mushroom poisoning cases is still a challenge, especially with the lack of authentic references. In this study, we developed an effective method for simultaneous identification of amanita peptide toxins by liquid chromatography coupled with photodiode array detection and ion trap time-of-flight mass spectrometry. The accuracy and selectivity of the methodology were validated through similar multiple fragmentation patterns and characteristic ions of standard alpha- and ss-amanitin. The developed method could successfully separate and identify major toxic constituents in Amanita mushrooms. Two amatoxins and three phallotoxins were confirmed in a single run through their fragmentation patterns and characteristic ions, which can be used as diagnostic fragment ions to identify mushroom toxins in complex samples. Furthermore, the performance of the developed method was verified by using real biological samples, including plasma and urine samples collected from rats after intraperitoneal administration of toxins. Thus, the development methodology could be crucial for the accurate detection of mushroom toxins without standard references.

Keyword :

Identification Amatoxin LC-PDA-IT-TOF-MS Phallotoxin

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GB/T 7714 Li, Chunlei , Qian, Hongyan , Bao, Tao et al. Simultaneous identification and characterization of amanita toxins using liquid chromatography-photodiode array detection-ion trap and time-offlight mass spectrometry and its applications [J]. | TOXICOLOGY LETTERS , 2018 , 296 : 95-104 .
MLA Li, Chunlei et al. "Simultaneous identification and characterization of amanita toxins using liquid chromatography-photodiode array detection-ion trap and time-offlight mass spectrometry and its applications" . | TOXICOLOGY LETTERS 296 (2018) : 95-104 .
APA Li, Chunlei , Qian, Hongyan , Bao, Tao , Yang, Guangde , Wang, Sicen , Liu, Xinshe . Simultaneous identification and characterization of amanita toxins using liquid chromatography-photodiode array detection-ion trap and time-offlight mass spectrometry and its applications . | TOXICOLOGY LETTERS , 2018 , 296 , 95-104 .
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Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injections EI SCIE Scopus
期刊论文 | 2018 , 6 (4) , 624-633 | JOURNAL OF MATERIALS CHEMISTRY B
WoS CC Cited Count: 1 SCOPUS Cited Count: 2
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Aiming at improving reliability and tedious analysis time in conventional cell membrane chromatography, an improved bioaffinity sample pretreatment technique with enhanced stability was developed to fast screen and extract potential allergenic components from traditional Chinese medicine injections. In this study, rat basophilic leukemia-2H3 cell membrane coated silica particles (RBL-2H3/CMCSPs) were fabricated by irreversible adsorption between the cell membrane and silica and self-fusion of the cell membrane, which could simulate drug-receptor interactions in vitro. Also, benefiting from the use of paraformaldehyde, the average recoveries of the six batches of RBL/CMCSPs were 90.2% with a relative standard deviation of less than 7.8%, showing that the stability of the materials was remarkably improved compared to materials without fixation. After the successful characterization by spectroscopic and imaging instruments, the prepared RBL-2H3/CMCSPs exhibited desirable adsorption capacity and selectivity. The RBL-2H3/CMCSPs combined with high performance liquid chromatography coupled with time of flight mass spectrometry were then successfully applied to screen and identify two potential allergenic components from huangqi injection, the allergenic activities of which were further investigated by beta-hexosaminidase release assay and histamine release assay in vitro. Overall, this work provides a good platform for the fabrication of bioaffinity sample pretreatment materials with high stability and a long lifespan, which can be a time-saving and energy-saving bioaffinity method to rapidly screen and preconcentrate target compounds from complex samples.

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GB/T 7714 Bu, Yusi , Hu, Qi , Xu, Ke et al. Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injections [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2018 , 6 (4) : 624-633 .
MLA Bu, Yusi et al. "Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injections" . | JOURNAL OF MATERIALS CHEMISTRY B 6 . 4 (2018) : 624-633 .
APA Bu, Yusi , Hu, Qi , Xu, Ke , Xie, Xiaoyu , Wang, Sicen . Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injections . | JOURNAL OF MATERIALS CHEMISTRY B , 2018 , 6 (4) , 624-633 .
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Liquid chromatography coupled with hybrid ion trap time-of-flight mass spectrometry method for the determination of caulophine in rat bio-samples and its pharmacokinetic study after intragastric and intraperitoneal administration EI SCIE PubMed Scopus
期刊论文 | 2018 , 41 (2) , 422-431 | JOURNAL OF SEPARATION SCIENCE
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A rapid and precise liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectrometry method to detect and quantify caulophine and its possible active metabolites in rat plasma and urine was developed. Samples were prepared by plasma protein precipitation combined with a liquid-liquid extraction method. The separation was carried out on an InertSustain (R) C18 column with a mobile phase comprising methanol and 0.1% aqueous formic acid solution. The analysis was complete in 20 min with a flow rate of 0.4 mL/min. Taspine was used as the internal standard. Mass spectrometric detection was conducted with hybrid ion trap/time-of-flight equipped with electrospray ionization in the positive ion mode. The calibration curves of caulophine were linear over the concentration ranges of 0.002-0.20 mu g/mL for plasma and 0.005-0.50 mu g/mL for urine with the correlation coefficients greater than 0.998 in both cases. The method was successfully used to investigate the pharmacokinetics and bioavailability in rat plasma and urine samples after intragastric and intraperitoneal administration of caulophine sodium salt.

Keyword :

pharmacokinetics caulophine metabolites mass spectrometry

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GB/T 7714 Lu, Dan , Xu, Xiao , Li, Chunlei et al. Liquid chromatography coupled with hybrid ion trap time-of-flight mass spectrometry method for the determination of caulophine in rat bio-samples and its pharmacokinetic study after intragastric and intraperitoneal administration [J]. | JOURNAL OF SEPARATION SCIENCE , 2018 , 41 (2) : 422-431 .
MLA Lu, Dan et al. "Liquid chromatography coupled with hybrid ion trap time-of-flight mass spectrometry method for the determination of caulophine in rat bio-samples and its pharmacokinetic study after intragastric and intraperitoneal administration" . | JOURNAL OF SEPARATION SCIENCE 41 . 2 (2018) : 422-431 .
APA Lu, Dan , Xu, Xiao , Li, Chunlei , Wang, Sicen . Liquid chromatography coupled with hybrid ion trap time-of-flight mass spectrometry method for the determination of caulophine in rat bio-samples and its pharmacokinetic study after intragastric and intraperitoneal administration . | JOURNAL OF SEPARATION SCIENCE , 2018 , 41 (2) , 422-431 .
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Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry SCIE PubMed Scopus
期刊论文 | 2018 , 29 (4) , 341-350 | PHYTOCHEMICAL ANALYSIS
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IntroductionCell membrane chromatography (CMC), as a highly selective type of affinity chromatography, has been demonstrated as an effective method to screen bioactive components acting on specific receptor from a complicated biological system. ObjectiveTo review the recent research progress and the technical applications of these analytical methods using CMC combined with gas chromatography-mass spectrometry, (GC/MS) and liquid chromatography-mass spectrometry (LC/MS). MethodologyIn this review, we briefly introduce the CMC offline GC/MS, CMC online GC/MS, CMC offline LC/MS, and CMC online LC/MS system. And the practical application of these technologies is also enumerated. Then the future of these technologies and research methods were discussed. ResultsMany bioactive components interacting with specific receptors have been screened and identified in traditional Chinese medicines. ConclusionCMC technique has been combined with GC/MS and HPLC/MS and these combined systems have been successfully used to screen bioactive components acting on specific receptors from a complicated biological system. We briefly introduce the CMC offline GC/MS, CMC online GC/MS, CMC offline LC/MS, and CMC online LC/MS system. And the practical application of these technologies is also enumerated. The CMC technique has been combined with GC/MS and HPLC/MS and these combined systems have been successfully used to screen bioactive components acting on specific receptors from a complicated biological system.

Keyword :

cell membrane chromatography liquid chromatography-mass spectrometry target components multi-dimensional chromatography gas chromatography-mass spectrometry

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GB/T 7714 Han, Shengli , Lv, Yanni , Wei, Fen et al. Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry [J]. | PHYTOCHEMICAL ANALYSIS , 2018 , 29 (4) : 341-350 .
MLA Han, Shengli et al. "Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry" . | PHYTOCHEMICAL ANALYSIS 29 . 4 (2018) : 341-350 .
APA Han, Shengli , Lv, Yanni , Wei, Fen , Fu, Jia , Hu, Qi , Wang, Sicen . Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry . | PHYTOCHEMICAL ANALYSIS , 2018 , 29 (4) , 341-350 .
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Characterization the affinity of alpha(1A) adrenoreceptor by cell membrane chromatography with frontal analysis and stoichiometric displacement model EI SCIE PubMed Scopus
期刊论文 | 2017 , 1040 , 273-281 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | IF: 2.441
WoS CC Cited Count: 5
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Abstract :

As a bionic chromatographic method, cell membrane chromatography (CMC) has been used widely in screening active components in traditional Chinese medicine. Nevertheless, few studies have characterized the affinity between drug and receptor by CMC model. In this study, the alpha 1 adrenoreceptor (alpha(1A) AR) high expression CMC method, combined with frontal analysis and stoichiometric displacement model respectively, was established for characterizing the affinity of seven alkaloids binding to the alpha(1A) AR. The results indicate that the seven alkaloids have similar interaction strengths with tamsulosin hydrochloride (alpha(1A) AR antagonist) between them and alpha(1A) AR. In addition, electrostatic force is the main intermolecular forces between tamsulosin hydrochloride and seven alkaloids and alpha(1A) AR. The study provides a versatile approach for the characterization the affinity between drug and receptor by CMC model. (C) 2016 Elsevier B.V. All rights reserved.

Keyword :

Cell membrane chromatography Frontal analysis alpha(1) Adrenoreceptor Stoichiometric displacement model

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GB/T 7714 Wei, Fen , Wang, Sicen , Lv, Nan et al. Characterization the affinity of alpha(1A) adrenoreceptor by cell membrane chromatography with frontal analysis and stoichiometric displacement model [J]. | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES , 2017 , 1040 : 273-281 .
MLA Wei, Fen et al. "Characterization the affinity of alpha(1A) adrenoreceptor by cell membrane chromatography with frontal analysis and stoichiometric displacement model" . | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1040 (2017) : 273-281 .
APA Wei, Fen , Wang, Sicen , Lv, Nan , Bu, Yusi , Xie, Xiaoyu . Characterization the affinity of alpha(1A) adrenoreceptor by cell membrane chromatography with frontal analysis and stoichiometric displacement model . | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES , 2017 , 1040 , 273-281 .
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A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine SCIE PubMed Scopus
期刊论文 | 2017 , 7 | SCIENTIFIC REPORTS | IF: 4.122
WoS CC Cited Count: 1
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We describe a novel biomembrane affinity sample pretreatment technique to quickly screen and preconcentrate active components from traditional Chinese medicine (TCM), which adopts cell membrane coated silica particles (CMCSPs) as affinity ligands which benefit the biomembrane's ability to maximize simulation of drug-receptor interactions in vivo. In this study, the prepared CMCSPs formed by irreversible adsorption of fibroblast growth factor receptor 4 (FGFR4) cell membrane on the surface of silica were characterized using different spectroscopic and imaging instruments. Drug binding experiments showed the excellent adsorption rate and adsorption capacity of FGFR4/CMCSPs compared with non-coated silica particles. The FGFR4/CMCSPs were used as solid-phase extraction sorbents to pretreat the TCM Aconitum szechenyianum Gay. The resultant FGFR4/CMCSPs exhibited good performance. In addition, high selectivity and recognition ability of the FGFR4/CMCSPs were determined by selectivity experiments. Four alkaloid were screened and identified, one of these alkaloid, napellonine, showed favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. The proposed cell membrane affinity sample pretreatment method is a reliable, effective and time-saving method for fast screening and enriching active compounds and can be extended to pretreat other TCMs as leading compounds resources.

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GB/T 7714 Bu, Yusi , He, Xiaoshuang , Hu, Qi et al. A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine [J]. | SCIENTIFIC REPORTS , 2017 , 7 .
MLA Bu, Yusi et al. "A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine" . | SCIENTIFIC REPORTS 7 (2017) .
APA Bu, Yusi , He, Xiaoshuang , Hu, Qi , Wang, Cheng , Xie, Xiaoyu , Wang, Sicen . A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine . | SCIENTIFIC REPORTS , 2017 , 7 .
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Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS EI SCIE Scopus
期刊论文 | 2017 , 9 (33) , 4828-4836 | ANALYTICAL METHODS | IF: 2.073
WoS CC Cited Count: 1
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Breast cancer is one of the most frequent malignant tumors in females. Extracts from Cortex Magnolia Officinalis (CMO) have shown the ability to inhibit the growth of breast cancer cells. In the present study, we developed MCF-7 cell membrane chromatography (CMC) combined with a UHPLC-ESI-MS/MS method to screen and identify the active components from the extract of CMO. Sorafenib and dexamethasone acetate were used as positive and negative control drugs, respectively, to investigate the suitability of this system. Under optimum experimental conditions, two components showed strong retention characteristics on the MCF-7 cell membrane chromatographic column. These compounds were identified as magnolol and honokiol by UHPLC-ESI-MS/MS. Cytotoxicity assay and Hoechst 33258 staining were done to investigate the anti-proliferative activity of the two compounds. The MTT results showed that MCF-7 cell viability decreased gradually in a dose-dependent manner during 48 h. The IC50 of magnolol and honokiol were 85.4 mu M and 58.1 mu M, respectively. After Hoechst 33258 staining, the cells were observed with bright blue nuclei due to karyopyknosis and chromatin condensation. The screening results showed that both magnolol and honokiol were promising active components of CMO extract having an inhibitory effect on MCF-7 cell growth. This two-dimensional method CMC-UHPLCESI- MS/MS could have potential utility for screening target components from traditional Chinese medicines.

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GB/T 7714 He, Xiaoshuang , Zhang, Ping , Saqib, Muhammad et al. Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS [J]. | ANALYTICAL METHODS , 2017 , 9 (33) : 4828-4836 .
MLA He, Xiaoshuang et al. "Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS" . | ANALYTICAL METHODS 9 . 33 (2017) : 4828-4836 .
APA He, Xiaoshuang , Zhang, Ping , Saqib, Muhammad , Hou, Xiaofang , Wang, Sicen . Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS . | ANALYTICAL METHODS , 2017 , 9 (33) , 4828-4836 .
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