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学者姓名:杨铁林

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Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females Scopus SCIE
期刊论文 | 2018 , 9 (21) , 3858-3866 | Journal of Cancer
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Abstract :

© Ivyspring International Publisher. Although genome-wide association studies (GWASs) have identified some risk single-nucleotide polymorphisms in East Asian never-smoking females, the unexplained missing heritability is still required to be investigated. Runs of homozygosity (ROHs) are thought to be a type of genetic variation acting on human complex traits and diseases. We detected ROHs in 8,881 East Asian never-smoking women. The summed ROHs were used to fit a logistic regression model which noteworthily revealed a significant association between ROHs and the decreased risk of lung cancer (P < 0.05). We identified 4 common ROHs regions located at 2p22.1, which were significantly associated with decreased risk of lung cancer (P = 2.00 × 10-4 - 1.35 × 10-4). Functional annotation was conducted to investigate the regulatory function of ROHs. The common ROHs were overlapped with potential regulatory elements, such as active epigenome elements and chromatin states in lung-derived cell lines. SOS1 and ARHGEF33 were significantly up-regulated as the putative target genes of the identified ROHs in lung cancer samples according to the analysis of differently expressed genes. Our results suggest that ROHs could act as recessive contributing factors and regulatory elements to influence the risk of lung cancer in never-smoking East Asian females.

Keyword :

Genetic risk factors GWASs Lung cancer Regulatory elements Runs of homozygosity

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GB/T 7714 Chen, Yi-Xiao , Guo, Yan , Dong, Shan-Shan et al. Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females [J]. | Journal of Cancer , 2018 , 9 (21) : 3858-3866 .
MLA Chen, Yi-Xiao et al. "Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females" . | Journal of Cancer 9 . 21 (2018) : 3858-3866 .
APA Chen, Yi-Xiao , Guo, Yan , Dong, Shan-Shan , Chen, Xiao-Feng , Chen, Jia-Bin , Zhang, Yu-Jie et al. Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females . | Journal of Cancer , 2018 , 9 (21) , 3858-3866 .
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V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis SCIE
期刊论文 | 2018 , 8 (19) , 5379-5399 | THERANOSTICS
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Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings connect subunits H and G1 with decreased bone density. Given the controversial effects of ATPase subunits on bone density, there is a critical need to review the subunits of V-ATPase in osteoclasts and their functions in regulating osteoclasts and bone remodeling. In this review, we comprehensively address the following areas: information about all V-ATPase subunits and their isoforms; summary of V-ATPase subunits associated with human genetic diseases; V-ATPase subunits and osteopetrosis/osteoporosis; screening of all V-ATPase subunits variants in GEFOS data and in-house data; spectrum of V-ATPase subunits during osteoclastogenesis; direct and indirect roles of subunits of V-ATPases in osteoclasts; V-ATPase-associated signaling pathways in osteoclasts; interactions among V-ATPase subunits in osteoclasts; osteoclast-specific V-ATPase inhibitors; perspective of future inhibitors or activators targeting V-ATPase subunits in the treatment of osteoporosis.

Keyword :

osteoclasts osteopetrosis signaling pathways pH inhibitor V-ATPase osteoporosis

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GB/T 7714 Duan, Xiaohong , Yang, Shaoqing , Zhang, Lei et al. V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis [J]. | THERANOSTICS , 2018 , 8 (19) : 5379-5399 .
MLA Duan, Xiaohong et al. "V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis" . | THERANOSTICS 8 . 19 (2018) : 5379-5399 .
APA Duan, Xiaohong , Yang, Shaoqing , Zhang, Lei , Yang, Tielin . V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis . | THERANOSTICS , 2018 , 8 (19) , 5379-5399 .
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Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis Scopus SCIE
期刊论文 | 2018 , 9 (23) , 4355-4362 | Journal of Cancer
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© Ivyspring International Publisher. Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The relevant publications were obtained by systematically searching the PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for the prognosis value of LAPTM4B-35 for cancer patient. Results: Our result suggest that LAPTM4B-35 overexpression is significantly associated with poor overall survival (OS) (HR = 2.49, 95% CI = 1.87-3.32, p < 0.001), disease-free survival (DFS) (HR = 2.43, 95% CI = 1.35-4.35, p = 0.003), and progression-free survival (PFS) (HR = 4.12, 95% CI = 2.30-7.37, p < 0.001). Moreover, subgroup analysis revealed significant association with poor OS in lung (HR = 2.05, 95% CI = 1.37-3.06, p < 0.001), gastric carcinoma (HR = 1.88, 95% CI = 1.01-3.50, p < 0.047) and ovarian cancer (HR = 4.94, 95% CI = 1.44-16.94, p = 0.011). Conclusion: LAPTM4B-35 may be a novel predictive biomarker and a potential target for treatment.

Keyword :

Cancer LAPTM4B-35 Meta-analysis Prognosis

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GB/T 7714 Zhou, Linghui , Dai, Cong , Tian, Tian et al. Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis [J]. | Journal of Cancer , 2018 , 9 (23) : 4355-4362 .
MLA Zhou, Linghui et al. "Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis" . | Journal of Cancer 9 . 23 (2018) : 4355-4362 .
APA Zhou, Linghui , Dai, Cong , Tian, Tian , Wang, Meng , Lin, Shuai , Deng, Yujiao et al. Prognostic values of LAPTM4B-35 in human cancer: A Meta-analysis . | Journal of Cancer , 2018 , 9 (23) , 4355-4362 .
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An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation SCIE PubMed Scopus
期刊论文 | 2018 , 102 (5) , 776-793 | AMERICAN JOURNAL OF HUMAN GENETICS
WoS CC Cited Count: 1
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Genome-wide association studies (GWASs) have reproducibly associated variants within intergenic regions of 1p36.12 locus with osteoporosis, but the functional roles underlying these noncoding variants are unknown. Through an integrative functional genomic and epigenomic analyses, we prioritized rs6426749 as a potential causal SNP for osteoporosis at 1p36.12. Dual-luciferase assay and CRISPR/ Cas9 experiments demonstrate that rs6426749 acts as a distal allele-specific enhancer regulating expression of a lncRNA (LINC00339) (similar to 360 kb) via long-range chromatin loop formation and that this loop is mediated by CTCF occupied near rs6426749 and LINC00339 promoter region. Specifically, rs6426749-G allele can bind transcription factor TFAP2A, which efficiently elevates the enhancer activity and increases LINC00339 expression. Downregulation of LINC00339 significantly increases the expression of CDC42 in osteoblast cells, which is a pivotal regulator involved in bone metabolism. Our study provides mechanistic insight into how a noncoding SNP affects osteoporosis by long-range interaction, a finding that could indicate promising therapeutic targets for osteoporosis.

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GB/T 7714 Chen, Xiao-Feng , Zhu, Dong-Li , Yang, Man et al. An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation [J]. | AMERICAN JOURNAL OF HUMAN GENETICS , 2018 , 102 (5) : 776-793 .
MLA Chen, Xiao-Feng et al. "An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation" . | AMERICAN JOURNAL OF HUMAN GENETICS 102 . 5 (2018) : 776-793 .
APA Chen, Xiao-Feng , Zhu, Dong-Li , Yang, Man , Hu, Wei-Xin , Duan, Yuan-Yuan , Lu, Bing-Jie et al. An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation . | AMERICAN JOURNAL OF HUMAN GENETICS , 2018 , 102 (5) , 776-793 .
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Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer SCIE PubMed Scopus
期刊论文 | 2018 , 33 (7) , 1335-1346 | JOURNAL OF BONE AND MINERAL RESEARCH
WoS CC Cited Count: 2 SCOPUS Cited Count: 3
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RANKL is a key regulator involved in bone metabolism, and a drug target for osteoporosis. The clinical diagnosis and assessment of osteoporosis are mainly based on bone mineral density (BMD). Previous powerful genomewide association studies (GWASs) have identified multiple intergenic single-nucleotide polymorphisms (SNPs) located over 100kb upstream of RANKL and 65kb downstream of AKAP11 at 13q14.11 for osteoporosis. Whether these SNPs exert their roles on osteoporosis through RANKL is unknown. In this study, we conducted integrative analyses combining expression quantitative trait locus (eQTL), genomic chromatin interaction (high-throughput chromosome conformation capture [Hi-C]), epigenetic annotation, and a series of functional assays. The eQTL analysis identified six potential functional SNPs (rs9533090, rs9594738, r8001611, rs9533094, rs9533095, and rs9594759) exclusively correlated with RANKL gene expression (p<0.001) at 13q14.11. Co-localization analyses suggested that eQTL signal for RANKL and BMD-GWAS signal shared the same causal variants. Hi-C analysis and functional annotation further validated that the first five osteoporosis SNPs are located in a super-enhancer region to regulate the expression of RANKL via long-range chromosomal interaction. Particularly, dual-luciferase assay showed that the region harboring rs9533090 in the super-enhancer has the strongest enhancer activity, and rs9533090 is an allele-specific regulatory SNP. Furthermore, deletion of the region harboring rs9533090 using CRISPR/Cas9 genome editing significantly reduced RANKL expression in both mRNA level and protein level. Finally, we found that the rs9533090-C robustly recruits transcription factor NFIC, which efficiently elevates the enhancer activity and increases the RANKL expression. In summary, we provided a feasible method to identify regulatory noncoding SNPs to distally regulate their target gene underlying the pathogenesis of osteoporosis by using bioinformatics data analyses and experimental validation. Our findings would be a potential and promising therapeutic target for precision medicine in osteoporosis. (c) 2018 American Society for Bone and Mineral Research.

Keyword :

LONG-RANGE CRISPR RANKL SUPER-ENHANCER CAS9 OSTEOPOROSIS

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GB/T 7714 Zhu, Dong-Li , Chen, Xiao-Feng , Hu, Wei-Xin et al. Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer [J]. | JOURNAL OF BONE AND MINERAL RESEARCH , 2018 , 33 (7) : 1335-1346 .
MLA Zhu, Dong-Li et al. "Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer" . | JOURNAL OF BONE AND MINERAL RESEARCH 33 . 7 (2018) : 1335-1346 .
APA Zhu, Dong-Li , Chen, Xiao-Feng , Hu, Wei-Xin , Dong, Shan-Shan , Lu, Bing-Jie , Rong, Yu et al. Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer . | JOURNAL OF BONE AND MINERAL RESEARCH , 2018 , 33 (7) , 1335-1346 .
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Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits SCIE PubMed Scopus
期刊论文 | 2018 , 19 (7) , 917-930 | OBESITY REVIEWS
WoS CC Cited Count: 1 SCOPUS Cited Count: 2
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Abstract :

We aimed to summarize the results of genetic association studies for obesity and provide a comprehensive annotation of all susceptibility single nucleotide polymorphisms (SNPs). A total of 72 studies were summarized, resulting in 90,361 susceptibility SNPs (738 index SNPs and 89,623 linkage disequilibrium SNPs). Over 90% of the susceptibility SNPs are located in non-coding regions, and it is challenging to understand their functional significance. Therefore, we annotated these SNPs by using various functional databases. We identified 24,623 functional SNPs, including 4 nonsense SNPs, 479 missense SNPs, 399 untranslated region SNPs which might affect microRNA binding, 262 promoter and 5,492 enhancer SNPs which might affect transcription factor binding, 7 splicing sites, 76 SNPs which might affect gene methylation levels, 1,839 SNPs under natural selection and 17,351 SNPs which might modify histone binding. Expression quantitative trait loci analyses for functional SNPs identified 98 target genes, including 69 protein coding genes, 27 long non-coding RNAs and 3 processed transcripts. The percentage of protein coding genes that could be correlated with obesity-related pathways directly or through gene-gene interaction is 75.36 (52/69). Our results may serve as an encyclopaedia of obesity susceptibility SNPs and offer guide for functional experiments.

Keyword :

obesity SNPs non-coding Annotation

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GB/T 7714 Dong, S. -S. , Zhang, Y. -J. , Chen, Y. -X. et al. Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits [J]. | OBESITY REVIEWS , 2018 , 19 (7) : 917-930 .
MLA Dong, S. -S. et al. "Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits" . | OBESITY REVIEWS 19 . 7 (2018) : 917-930 .
APA Dong, S. -S. , Zhang, Y. -J. , Chen, Y. -X. , Yao, S. , Hao, R. -H. , Rong, Y. et al. Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits . | OBESITY REVIEWS , 2018 , 19 (7) , 917-930 .
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Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis SCIE PubMed Scopus
期刊论文 | 2017 , 136 (8) , 963-974 | HUMAN GENETICS | IF: 3.93
WoS CC Cited Count: 1
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Despite genome-wide association studies (GWASs) have identified many susceptibility genes for osteoporosis, it still leaves a large part of missing heritability to be discovered. Integrating regulatory information and GWASs could offer new insights into the biological link between the susceptibility SNPs and osteoporosis. We generated five machine learning classifiers with osteoporosis-associated variants and regulatory features data. We gained the optimal classifier and predicted genome-wide SNPs to discover susceptibility regulatory variants. We further utilized Genetic Factors for Osteoporosis Consortium (GEFOS) and three in-house GWASs samples to validate the associations for predicted positive SNPs. The random forest classifier performed best among all machine learning methods with the F1 score of 0.8871. Using the optimized model, we predicted 37,584 candidate SNPs for osteoporosis. According to the meta-analysis results, a list of regulatory variants was significantly associated with osteoporosis after multiple testing corrections and contributed to the expression of known osteoporosis-associated protein-coding genes. In summary, combining GWASs and regulatory elements through machine learning could provide additional information for understanding the mechanism of osteoporosis. The regulatory variants we predicted will provide novel targets for etiology research and treatment of osteoporosis.

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GB/T 7714 Yao, Shi , Guo, Yan , Dong, Shan-Shan et al. Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis [J]. | HUMAN GENETICS , 2017 , 136 (8) : 963-974 .
MLA Yao, Shi et al. "Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis" . | HUMAN GENETICS 136 . 8 (2017) : 963-974 .
APA Yao, Shi , Guo, Yan , Dong, Shan-Shan , Hao, Ruo-Han , Chen, Xiao-Feng , Chen, Yi-Xiao et al. Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis . | HUMAN GENETICS , 2017 , 136 (8) , 963-974 .
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A functional SNP regulated by miR-196a-3p in the 3UTR of FGF2 is associated with bone mineral density in the Chinese population SCIE PubMed Scopus
期刊论文 | 2017 , 38 (6) , 725-735 | HUMAN MUTATION | IF: 5.359
WoS CC Cited Count: 5
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Abstract :

Previous studies have identified FGF2 as a susceptibility gene for osteoporosis in Caucasians. Evaluating the genetic associations in different ethnicities is necessary. Moreover, elucidating the functional mechanism for the susceptibility loci is important to offer new targets for therapeutic studies. Here, we genotyped 10 SNPs in FGF2 and tested for associations with bone mineral density (BMD) in a discovery sample of 1,300 Chinese subjects. Nominally significant results were subjected to replication in another sample of 1,039 Chinese subjects. We identified one SNP rs1048201:C>T in FGF2 3untranslated region significantly associated with spine BMD (combined cohorts, P = 1.53x10(-3)). Expression quantitative trait locus analyses revealed that rs1048201 also affected FGF2 gene expression (P = 7.03x10(-4)). Bioinformatics prediction suggested that rs1048201 T allele could disrupt miRNA binding. Luciferase assay validated that the C allele had a repressive effect on FGF2 gene expression. We found that hsa-miR-196a-3p affected expression on both mRNA and protein levels of FGF2. In conclusion, our study provided evidence that a functional SNP rs1048201 was associated with BMD, and SNP rs1048201:C>T variant may act by affecting binding of hsa-miR-196a-3p. The SNP-modified posttranscriptional gene regulation by miRNA could be a potentially pathogenetic mechanism of osteoporosis.

Keyword :

eQTL 3UTR miR-196a-3p SNP FGF2 osteoporosis

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GB/T 7714 Zhu, Dong-Li , Guo, Yan , Zhang, Yan et al. A functional SNP regulated by miR-196a-3p in the 3UTR of FGF2 is associated with bone mineral density in the Chinese population [J]. | HUMAN MUTATION , 2017 , 38 (6) : 725-735 .
MLA Zhu, Dong-Li et al. "A functional SNP regulated by miR-196a-3p in the 3UTR of FGF2 is associated with bone mineral density in the Chinese population" . | HUMAN MUTATION 38 . 6 (2017) : 725-735 .
APA Zhu, Dong-Li , Guo, Yan , Zhang, Yan , Dong, Shan-Shan , Xu, Wen , Hao, Ruo-Han et al. A functional SNP regulated by miR-196a-3p in the 3UTR of FGF2 is associated with bone mineral density in the Chinese population . | HUMAN MUTATION , 2017 , 38 (6) , 725-735 .
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Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits SCIE PubMed Scopus
期刊论文 | 2016 , 40 (7) , 1170-1176 | INTERNATIONAL JOURNAL OF OBESITY | IF: 5.487
WoS CC Cited Count: 2
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OBJECTIVES: With ENCODE epigenomic data and results from published genome-wide association studies (GWASs), we aimed to find regulatory signatures of obesity genes and discover novel susceptibility genes. METHODS: Obesity genes were obtained from public GWAS databases and their promoters were annotated based on the regulatory element information. Significantly enriched or depleted epigenomic elements in the promoters of obesity genes were evaluated and all human genes were then prioritized according to the existence of the selected elements to predict new candidate genes. Top-ranked genes were subsequently applied to validate their associations with obesity-related traits in three independent in-house GWAS samples. RESULTS: We identified RAD21 and EZH2 as over-represented, and STAT2 (signal transducer and activator of transcription 2) and IRF3 (interferon regulatory transcription factor 3) as depleted transcription factors. Histone modification of H3K9me3 and chromatin state segmentation of 'poised promoter' and 'repressed' were over-represented. All genes were prioritized and we selected the top five genes for validation at the population level. Combining results from the three GWAS samples, rs7522101 in ESRRG (estrogenrelated receptor-gamma) remained significantly associated with body mass index after multiple testing corrections (P = 7.25 x 10(-5)). It was also associated with beta-cell function (P = 1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set. CONCLUSIONS: In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene.

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GB/T 7714 Dong, S-S , Guo, Y. , Zhu, D-L et al. Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits [J]. | INTERNATIONAL JOURNAL OF OBESITY , 2016 , 40 (7) : 1170-1176 .
MLA Dong, S-S et al. "Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits" . | INTERNATIONAL JOURNAL OF OBESITY 40 . 7 (2016) : 1170-1176 .
APA Dong, S-S , Guo, Y. , Zhu, D-L , Chen, X-F , Wu, X-M , Shen, H. et al. Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits . | INTERNATIONAL JOURNAL OF OBESITY , 2016 , 40 (7) , 1170-1176 .
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Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population SCIE PubMed Scopus
期刊论文 | 2016 , 6 | SCIENTIFIC REPORTS | IF: 4.259
WoS CC Cited Count: 6 SCOPUS Cited Count: 3
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Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear. This study aimed to investigate the associations of both the plasma FGF2 levels and SNPs in FGF2 gene with obesity phenotypes in Han Chinese populations. Plasma FGF2 levels were measured and subjected to association analyses in 62 subjects. Eleven SNPs in FGF2 were genotyped and tested for associations in a discovery sample of 1,300 subjects. SNPs significantly associated with obesity were subjected to replication in another independent sample of 1,035 subjects. We found that plasma FGF2 levels were positively correlated with fat mass (P = 0.010). Association analyses in the discovery sample identified three SNPs (rs1449683, rs167428, rs308442) significantly associated with fat mass after multiple testing adjustments (P < 0.0045). Subsequent replication study successfully validated one SNP (rs167428) associated with fat mass (P-combine = 3.46 x 10(-5)). eQTL analyses revealed that SNPs associated with obesity also affected FGF2 expression. Our findings suggested that high plasma FGF2 level correlated with increased risk of obesity, and FGF2 gene polymorphisms could affect individual variances of obesity in Han Chinese population.

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GB/T 7714 Hao, Ruo-Han , Guo, Yan , Dong, Shan-Shan et al. Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population [J]. | SCIENTIFIC REPORTS , 2016 , 6 .
MLA Hao, Ruo-Han et al. "Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population" . | SCIENTIFIC REPORTS 6 (2016) .
APA Hao, Ruo-Han , Guo, Yan , Dong, Shan-Shan , Weng, Gai-Zhi , Yan, Han , Zhu, Dong-Li et al. Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population . | SCIENTIFIC REPORTS , 2016 , 6 .
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