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Identifying suspicious groups of affiliated-transaction-based tax evasion in big data EI Scopus
期刊论文 | 2019 , 477 , 508-532 | Information Sciences
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Abstract :

© 2018 Elsevier Inc. Affiliated-transaction-based tax evasion (ATTE) is a new strategy in tax evasion that is carried out via legal-like transactions between a group of companies that have heterogeneous, complex and covert interactive relationships to evade taxes. Existing studies cannot effectively detect ATTE behaviors since (i) they perform well only for determining the abnormal financial status of individuals and ineffectively address the interactive relationships among companies, (ii) they aim at detecting ATTE from the perspective of structural characteristics, which leads to a poor false-positive rate, and (iii) few of them perform well in most sectors of companies. Effectively detecting suspicious groups according to both structural characteristics of ATTE groups and business characteristics of ATTE means (BC-ATTEM) remains an open issue. In this paper, we propose an affiliated-parties interest-related network (APIRN) for modeling affiliated parties, interest-related relationships, and their properties for identifying ATTE. Then, we identify the behavioral patterns of ATTE via topological pattern abstraction from APIRN and theoretical inference of BC-ATTEM. Based on the above, we further propose a hybrid method, namely, 3TI, for identifying ATTE suspicious groups via three steps: tax rate differential detection, topological pattern matching and tax burden abnormality identification. Experimental tests that are based on two years of real-world tax data from a province in China demonstrate that 3TI can identify ATTE suspicious groups with higher accuracy and better generality than existing works. Moreover, we identify various interesting implications and provide useful guidance for ATTE inspection based on an analysis of our experimental results.

Keyword :

Affiliated transaction Big data Graph mining Tax evasion

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GB/T 7714 Ruan, Jianfei , Yan, Zheng , Dong, Bo et al. Identifying suspicious groups of affiliated-transaction-based tax evasion in big data [J]. | Information Sciences , 2019 , 477 : 508-532 .
MLA Ruan, Jianfei et al. "Identifying suspicious groups of affiliated-transaction-based tax evasion in big data" . | Information Sciences 477 (2019) : 508-532 .
APA Ruan, Jianfei , Yan, Zheng , Dong, Bo , Zheng, Qinghua , Qian, Buyue . Identifying suspicious groups of affiliated-transaction-based tax evasion in big data . | Information Sciences , 2019 , 477 , 508-532 .
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C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes SCIE PubMed Scopus
期刊论文 | 2018 , 8 | SCIENTIFIC REPORTS
WoS CC Cited Count: 1
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Abstract :

Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles of C10orf99 in epidermal proliferation under inflammatory condition. We showed that C10orf99 protein was significantly up-regulated in psoriatic skin samples from patients and the ortholog gene expression levels were up-regulated in imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. Using M5-stimulated HaCaT cell line model of inflammation and a combinational approach of knockdown and overexpression of C10orf99, we demonstrated that C10orf99 could promote keratinocyte proliferation by facilitating the G1/S transition, and the pro-proliferation effect of C10orf99 was associated with the activation of the ERK1/2 and NF-kappa B but not the AKT pathways. Local depletion of C10orf99 by lentiviral vectors expressing C10orf99 shRNA effectively ameliorated IMQ-induced dermatitis. Taken together, these results indicate that C10orf99 plays a contributive role in psoriasis pathogenesis and may serve as a new target for psoriasis treatment.

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GB/T 7714 Chen, Caifeng , Wu, Na , Duan, Qiqi et al. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes [J]. | SCIENTIFIC REPORTS , 2018 , 8 .
MLA Chen, Caifeng et al. "C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes" . | SCIENTIFIC REPORTS 8 (2018) .
APA Chen, Caifeng , Wu, Na , Duan, Qiqi , Yang, Huizi , Wang, Xin , Yang, Peiwen et al. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes . | SCIENTIFIC REPORTS , 2018 , 8 .
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Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway SCIE PubMed Scopus
期刊论文 | 2018 , 8 | SCIENTIFIC REPORTS
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Psoriasis is a chronic inflammatory skin disease with high morbidity, poor treatment methods and high rates of relapse. Keratinocyte hyperproliferation and shortened cell cycles are important pathophysiological features of psoriasis. As a known oncogene, Yes-associated protein (YAP) plays a role in promoting cell proliferation and inhibiting cell apoptosis; however, whether YAP is involved in the pathogenesis of psoriasis remains to be determined. Amphiregulin (AREG), a transcriptional target of YAP, was found to be upregulated in psoriasis, and overexpression of AREG promoted keratinocyte proliferation. In the present study, immunohistochemistry showed that YAP expression was elevated in the skin of psoriasis patients and in the Imiquimod (IMQ) mouse model of psoriasis. Knockdown of YAP in HaCaT cells inhibited cell proliferation, caused cell cycle arrest in G0/G1 phase and promoted apoptosis. These changes in YAP-knockdown HaCaT cells were related to changes in AREG expression. We concluded that YAP may play an important role in the regulation of abnormal keratinocyte proliferation via an AREG-dependent pathway and that YAP could be a new target in the treatment of psoriasis.

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GB/T 7714 Jia, Jinjing , Li, Changji , Yang, Jiao et al. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway [J]. | SCIENTIFIC REPORTS , 2018 , 8 .
MLA Jia, Jinjing et al. "Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway" . | SCIENTIFIC REPORTS 8 (2018) .
APA Jia, Jinjing , Li, Changji , Yang, Jiao , Wang, Xin , Li, Ruilian , Luo, Suju et al. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway . | SCIENTIFIC REPORTS , 2018 , 8 .
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Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells SCIE PubMed Scopus
期刊论文 | 2017 , 15 (1) , 240-248 | MOLECULAR MEDICINE REPORTS | IF: 1.922
WoS CC Cited Count: 3
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Abstract :

The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL-37 serves a functional role in the development of numerous types of cancer including ovarian, breast, prostate and lung cancer. However, its role in the development of malignant melanoma (MM) remains unclear. To determine the role of LL-37 and the potential interaction with Y-box binding protein 1 (YB-1) in MM, RNA interference, western blot, reverse transcription-quantitative polymerase chain reaction, MTT and Transwell assays were performed. The current study demonstrated that LL-37 induced YB-1 expression, and increased tumor cell proliferation, migration and invasion of A375 and A875 MM cell lines. In addition, inhibition of nuclear factor-kappa B (NF-kappa B) attenuated LL-37-induced YB-1 expression. These results demonstrate that, through the upregulation of YB-1 expression and the activation of the NF-kappa B signaling pathway, LL-37 may promote the malignant progression of MM cells in vitro.

Keyword :

Y-box binding protein 1 nuclear factor-kappa B LL-37 malignant melanoma

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GB/T 7714 Jia, Jinjing , Zheng, Yan , Wang, Wei et al. Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells [J]. | MOLECULAR MEDICINE REPORTS , 2017 , 15 (1) : 240-248 .
MLA Jia, Jinjing et al. "Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells" . | MOLECULAR MEDICINE REPORTS 15 . 1 (2017) : 240-248 .
APA Jia, Jinjing , Zheng, Yan , Wang, Wei , Shao, Yongping , Li, Zhengxiao , Wang, Qiong et al. Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells . | MOLECULAR MEDICINE REPORTS , 2017 , 15 (1) , 240-248 .
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Primary cutaneous diffuse large B cell lymphomaother successfully treated by the combination of R-CHOP chemotherapy and surgery A case report and review of literature SCIE PubMed Scopus
期刊论文 | 2017 , 96 (8) | MEDICINE | IF: 2.028
WoS CC Cited Count: 2
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Abstract :

Rationale: The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP ( A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed. Patient concerns: The patient was a 56-year-old female, presenting with red plaques and nodules in her left breast for 6 months. Diagnoses: Based on the clinical manifestation, histopathological and immunohistochemical results, the patient was diagnosed with PCDLBCL-O. Interventions: She was treated with 6 courses of R-CHOP chemotherapy combined with surgical resection. Outcomes: In the present case, fairly good curative effect was appeared with no recurrence within the 3 years' follow-up. Lessons: Primary cutaneous diffuse large B cell lymphoma commonly occurs on the legs ( leg type), rarely on other sites of the body. The clinical manefestations are so variant that its diagnosis depends on histopathological and immunohistochemical examinations. Like systemic diffuse large B cell lymphoma, patients should be treated with systemic chemotherapy. Abbreviations: CR = complete remission, DLBCL = diffuse large B cell lymphoma, PCBCL = primary cutaneous B cell lymphoma, PCDLBCL = primary cutaneous diffuse large B cell lymphoma, PCFCL = primary cutaneous follicle-center lymphoma, PCMZL = primary cutaneous marginal zone B cell lymphoma.

Keyword :

R-CHOP chemotherapy diffuse large B cell lymphoma skin perforation B cell lymphoma

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GB/T 7714 Jia, Jinjing , Li, Wensheng , Zheng, Yan . Primary cutaneous diffuse large B cell lymphomaother successfully treated by the combination of R-CHOP chemotherapy and surgery A case report and review of literature [J]. | MEDICINE , 2017 , 96 (8) .
MLA Jia, Jinjing et al. "Primary cutaneous diffuse large B cell lymphomaother successfully treated by the combination of R-CHOP chemotherapy and surgery A case report and review of literature" . | MEDICINE 96 . 8 (2017) .
APA Jia, Jinjing , Li, Wensheng , Zheng, Yan . Primary cutaneous diffuse large B cell lymphomaother successfully treated by the combination of R-CHOP chemotherapy and surgery A case report and review of literature . | MEDICINE , 2017 , 96 (8) .
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An unusual case of multiple cutaneous Rosai-Dorfman disease involving two separate parts of the body SCIE PubMed Scopus
期刊论文 | 2017 , 56 (5) , 576-578 | INTERNATIONAL JOURNAL OF DERMATOLOGY | IF: 1.541
WoS CC Cited Count: 1
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GB/T 7714 Jia, Jinjing , Tian, Qiong , Zhang, Haitao et al. An unusual case of multiple cutaneous Rosai-Dorfman disease involving two separate parts of the body [J]. | INTERNATIONAL JOURNAL OF DERMATOLOGY , 2017 , 56 (5) : 576-578 .
MLA Jia, Jinjing et al. "An unusual case of multiple cutaneous Rosai-Dorfman disease involving two separate parts of the body" . | INTERNATIONAL JOURNAL OF DERMATOLOGY 56 . 5 (2017) : 576-578 .
APA Jia, Jinjing , Tian, Qiong , Zhang, Haitao , Zheng, Yan . An unusual case of multiple cutaneous Rosai-Dorfman disease involving two separate parts of the body . | INTERNATIONAL JOURNAL OF DERMATOLOGY , 2017 , 56 (5) , 576-578 .
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Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 SCIE PubMed Scopus
期刊论文 | 2017 , 14 (1) , 499-506 | EXPERIMENTAL AND THERAPEUTIC MEDICINE | IF: 1.41
WoS CC Cited Count: 2 SCOPUS Cited Count: 3
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Abstract :

Antimicrobial peptide LL-37 serves a function in the host defense against microbial invasion, and also regulates cell proliferation, immune activity and angiogenesis. Previous studies have reported that LL-37 participates in the development of numerous tumour types, such as ovarian cancer, lung cancer, melanoma and breast cancer. However, the function of LL-37 in the development of skin squamous cell carcinoma (SCC) has not yet been fully elucidated. The aim of the current study was to investigate how LL-37 promotes the expression of Y-box binding protein 1 (YB-1) in SCC. Short interfering RNA (siRNA) was used to inhibit the expression of YB-1, and in vitro MTT and Transwell migration assays were used to evaluate the effect of reduced YB-1 on the viability and invasion of A431 cells. A431 cells were stimulated with LL-37, and quantitative polymerase chain reaction, immunofluorescence and western blot analyses were used to detect changes in YB-1 expression. Mitogen-activated protein kinase kinase, mitogen-activated protein kinase and nuclear factor (NF)-kappa B signaling pathway inhibitors were also used to evaluate the mechanism of LL-37-induced YB-1 protein expression. It was found that YB-1 expression was increased in SCC tissue compared with normal tissue. Inhibiting YB-1 expression using siRNA significantly reduced the viability and suppressed the invasion of tumour cells (P<0.05 for both). LL-37 treatment at 0.05 mu g/ml for 24 or 48 h significantly promoted YB-1 protein expression (P<0.05), and this was dependent on the NF-kappa B signaling pathway. In conclusion, the current study demonstrated that by upregulating the expression of YB-1, LL-37 can promote the occurrence and development of SCC, and this process involves the NF-kappa B signaling pathway.

Keyword :

squamous cell carcinoma Y-box binding protein 1 epidermis growth factor receptor LL-37 nuclear factor-kappa B

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GB/T 7714 Wang, Wei , Zheng, Yan , Jia, Jinjing et al. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 [J]. | EXPERIMENTAL AND THERAPEUTIC MEDICINE , 2017 , 14 (1) : 499-506 .
MLA Wang, Wei et al. "Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1" . | EXPERIMENTAL AND THERAPEUTIC MEDICINE 14 . 1 (2017) : 499-506 .
APA Wang, Wei , Zheng, Yan , Jia, Jinjing , Li, Changji , Duan, Qiqi , Li, Ruilian et al. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 . | EXPERIMENTAL AND THERAPEUTIC MEDICINE , 2017 , 14 (1) , 499-506 .
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The progression of CD56(+) myeloid sarcoma: A case report and literature review SCIE Scopus
期刊论文 | 2016 , 11 (5) , 3091-3096 | ONCOLOGY LETTERS | IF: 1.39
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The current study presents a case of cluster of differentiation (CD) 56(+) myeloid sarcoma in a patient that initially presented with skin lesions, and provides evidence for the clinical and differential diagnosis of myeloid sarcoma. The patient of the present case report was a 65-year-old man who was admitted to hospital with a six-month history of bilateral purple-red papules and nodules, which were present on the upper limbs of the patient and had spread over his whole body one month prior to admission to the hospital. Pathological examination demonstrated a diffuse infusion of primitive round cells at the papillary dermis and subcutaneous tissues. The infiltrated cells were 40-60 mu m in diameter and morphologically identical. Immunohistochemical examination revealed that the cells expressed myeloperoxidase, CD56, CD43 and T-cell intracytoplasmic antigen. In addition, several cells expressed CD34, and 90% of the cells expressed Ki67. While the majority of cells in myeloid sarcoma do not express CD56, the present case was a myeloid sarcoma that expressed CD56, which is extremely rare. The sarcoma in the present patient progressed rapidly, and the patient died eight months following the onset of disease. Clinicians should be aware of CD56(+) myeloid sarcoma, which is easily misdiagnosed and inappropriately treated. Consequently, myeloid sarcoma may have a high malignancy and poor outcome for patients.

Keyword :

Ki67 immunohistochemistry CD56 granulocytic sarcoma myeloid sarcoma

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GB/T 7714 Wang, Xin , Li, Wen-Sheng , Zheng, Yan et al. The progression of CD56(+) myeloid sarcoma: A case report and literature review [J]. | ONCOLOGY LETTERS , 2016 , 11 (5) : 3091-3096 .
MLA Wang, Xin et al. "The progression of CD56(+) myeloid sarcoma: A case report and literature review" . | ONCOLOGY LETTERS 11 . 5 (2016) : 3091-3096 .
APA Wang, Xin , Li, Wen-Sheng , Zheng, Yan , Ying, Zhao-Xia , Wang, Yong-Xian , Wang, Ying-Mei et al. The progression of CD56(+) myeloid sarcoma: A case report and literature review . | ONCOLOGY LETTERS , 2016 , 11 (5) , 3091-3096 .
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DNA Motifs and Transcription Factor Binding Sites Analysis of Regulatory Regions of MicroRNAs Relating to Psoriasis Disease CPCI-S
会议论文 | 2016 , 322-325 | Joint Conferences of International Conference on Computer Science and Engineering Technology (CSET) / International Conference on Medical Science and Biological Engineering (MSBE)
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Psoriasis is a complex disease, in which microRNAs played an important role in regulating target genes, and thus affecting gene expression and conducting cell proliferation. To analysis the regulation of microRNAs, and to illustrate the interaction of microRNAs with psoriasis related genes, we analyzed the upstream regions of the differentially expressed microRNAs relating to psoriasis. The polymerase binding site motifs were discovered by MAST using profiles of 13 polymerases in the upstream region for each microRNA, and a SVM (Support Vector Machine) was used to identify the motifs mostly related to microRNA expression level. Result shows that motif 3 and motif 6 are key to the gene expression type of psoriasis related microRNAs.

Keyword :

psoriasis transcription factors microRNAs Gene expression regulation

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GB/T 7714 Wang, Lina , Jing, Yuxiao , Du, Jianqiang et al. DNA Motifs and Transcription Factor Binding Sites Analysis of Regulatory Regions of MicroRNAs Relating to Psoriasis Disease [C] . 2016 : 322-325 .
MLA Wang, Lina et al. "DNA Motifs and Transcription Factor Binding Sites Analysis of Regulatory Regions of MicroRNAs Relating to Psoriasis Disease" . (2016) : 322-325 .
APA Wang, Lina , Jing, Yuxiao , Du, Jianqiang , Wu, Xiaoming , Guo, Jiaqi , Zheng, Yan . DNA Motifs and Transcription Factor Binding Sites Analysis of Regulatory Regions of MicroRNAs Relating to Psoriasis Disease . (2016) : 322-325 .
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Transcriptome Analysis Identified Feature Genes and Enriched Gene Functions Relating to Psoriasis CPCI-S
会议论文 | 2016 , 374-377 | Joint Conferences of International Conference on Computer Science and Engineering Technology (CSET) / International Conference on Medical Science and Biological Engineering (MSBE)
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Psoriasis is an inflammatory chronic disorder mediated by cells of immune systems. To know more about the pathogenesis underlying differentially expressed genes (DEGs) of psoriasis, we used all the 64102 annotated genes to assay the transcriptome of psoriatic and normal skin based upon public available RNA-Seq data. We identified 2906 DEGs (p.adj<0.05), of which 1365 were down-regulated and 1541 were up-regulated in psoriasis. Transcription-factor binding sites (TFBS) of NFKBRELA, IRF1, STAT1 showed significantly enriched among the up-regulated DEGs. We also confirmed that cytokines in immune system play an important role in psoriasis.

Keyword :

Psoriasis cytokine RNA-Seq inflammation transcriptome

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GB/T 7714 Guo, Jiaqi , Zheng, Yan , Wang, Lina et al. Transcriptome Analysis Identified Feature Genes and Enriched Gene Functions Relating to Psoriasis [C] . 2016 : 374-377 .
MLA Guo, Jiaqi et al. "Transcriptome Analysis Identified Feature Genes and Enriched Gene Functions Relating to Psoriasis" . (2016) : 374-377 .
APA Guo, Jiaqi , Zheng, Yan , Wang, Lina , Jing, Yuxiao , Du, Jianqiang , Wu, Xiaoming . Transcriptome Analysis Identified Feature Genes and Enriched Gene Functions Relating to Psoriasis . (2016) : 374-377 .
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