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Heterogeneous oxidization of graphene nanosheets damages membrane SCIE
期刊论文 | 2019 , 62 (6) | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
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Abstract :

Graphene-based materials exhibit unique properties that have been sought to utilize for various potential applications. Many studies suggest that graphene-based materials can be cytotoxic, which may be attributed to destructive effects on cell membranes. However, there still are conflicting results regarding interactions between graphene-based materials and lipid membranes. Here, through cryo-electron microscopy (Cryo-EM) and dye-leakage experiments along with in silico methods, we found that graphene oxide nanosheets induce significant membrane damage, while the effect of pristine graphene is negligible. We revealed the importance of heterogeneous oxidization of graphene-based nanosheets in damaging vesicle membranes. Moreover, that not only the oxidization degree but also the oxidization loci and membrane tension play important roles in the cytotoxicity of the graphene-based nanosheets.

Keyword :

cytotoxicity lipid membrane graphene graphene oxide heterogeneous oxidization

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GB/T 7714 Wang, QianChun , Zhai, XiaoBo , Crowe, Michael et al. Heterogeneous oxidization of graphene nanosheets damages membrane [J]. | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY , 2019 , 62 (6) .
MLA Wang, QianChun et al. "Heterogeneous oxidization of graphene nanosheets damages membrane" . | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 62 . 6 (2019) .
APA Wang, QianChun , Zhai, XiaoBo , Crowe, Michael , Gou, Lu , Li, YinFeng , Li, DeChang et al. Heterogeneous oxidization of graphene nanosheets damages membrane . | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY , 2019 , 62 (6) .
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LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis Scopus SCIE
期刊论文 | 2019 , 109 , 1140-1147 | Biomedicine and Pharmacotherapy
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Abstract :

© 2018 Elsevier Masson SAS Long non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 antisense RNA 1 (KTN1-AS1) has been reported to play an important role in colorectal cancer and correlates with unfavorable clinical outcomes of head and neck squamous cell carcinoma. However, the clinical significance and functional role of KTN1-AS1 in HCC are still unclear. Here, we found that KTN1-AS1 was a highly expressed lncRNA in HCC according to public available databases and our HCC cohort. Further analyses revealed that higher expression of KTN1-AS1 was observed in HCC tissues with large tumor size, high tumor grade and advanced TNM stage. Analysis of survival data indicated that high KTN1-AS1 expression was prominently correlated with poor clinical outcomes of HCC patients. Functionally, KTN1-AS1 knockdown suppressed cell proliferation and colony formation, and increased apoptosis of SMMC-7721 cells in vitro. Furthermore, silencing of KTN1-AS1 restrained tumor growth of HCC in vivo. Conversely, forced expression of KTN1-AS1 facilitated Huh7 cell proliferation and inhibited apoptosis. Mechanistically, KTN1-AS1 inversely regulated miR-23c abundance in HCC cells. Further evidence supported that KTN1-AS1 acted as a competing endogenous RNA (ceRNA) by directly sponging miR-23c in HCC cells. Interestingly, erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1 and its restoration reversed KTN1-AS1 knockdown attenuated HCC cell growth. To conclude, our study sheds light on the novel function and underlying mechanism of KTN1-AS1 in HCC, which may accelerate the development of cancer therapy.

Keyword :

ERBB2IP Hepatocellular carcinoma KTN1-AS1 miR-23c Tumor growth

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GB/T 7714 Zhang, Lei , Wang, Liang , Wang, Yufeng et al. LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis [J]. | Biomedicine and Pharmacotherapy , 2019 , 109 : 1140-1147 .
MLA Zhang, Lei et al. "LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis" . | Biomedicine and Pharmacotherapy 109 (2019) : 1140-1147 .
APA Zhang, Lei , Wang, Liang , Wang, Yufeng , Chen, Tianxiang , Liu, Runkun , Yang, Wei et al. LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis . | Biomedicine and Pharmacotherapy , 2019 , 109 , 1140-1147 .
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Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors EI SCIE Scopus CSCD
期刊论文 | 2018 , 27 (1) | CHINESE PHYSICS B
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Abstract :

Neuraminidase (NA), a major surface glycoprotein of influenza virus with well-defined active sites, is an ideal platform for the development of antiviral drugs. However, a growing number of NA mutations have drug resistance to today's inhibitors. Numerous efforts are made to explore the resistance mechanisms through understanding the structural changes in mutated NA proteins and the associated different binding profiles of inhibitors, via x-ray, nuclear magnetic resonance, electron microscopy, and molecular dynamics methods. This review presents the architectural features of mutated NA proteins, as well as the respective inhibitor sensitivities arising from these spatial differences. Finally, we summarize the resistance mechanisms of today's neuraminidase inhibitors and the outlook for the development of novel inhibitors.

Keyword :

inhibitor sensitivity active sites mutation neuraminidase

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GB/T 7714 Yang, Zhi-wei , Hao, Dong-xiao , Che, Yi-zhuo et al. Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors [J]. | CHINESE PHYSICS B , 2018 , 27 (1) .
MLA Yang, Zhi-wei et al. "Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors" . | CHINESE PHYSICS B 27 . 1 (2018) .
APA Yang, Zhi-wei , Hao, Dong-xiao , Che, Yi-zhuo , Yang, Jia-hui , Zhang, Lei , Zhang, Sheng-li . Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors . | CHINESE PHYSICS B , 2018 , 27 (1) .
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Wavenumber-Splitting Metasurfaces Achieve Multichannel Diffusive Invisibility EI SCIE Scopus
期刊论文 | 2018 , 6 (10) | ADVANCED OPTICAL MATERIALS
WoS CC Cited Count: 9
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Abstract :

The emerging invisibility schemes mainly adopt transformation optics, scattering cancellation, light diffusion, and metasurface-based phase restoration techniques. However, those aforementioned invisibility achievements natively depend on the predefined curvature, polarization, frequency, and/or angle of the incident wave. Here, an invisibility strategy of using an ultrathin parabolic-phase metasurface and its applications to achieve diffusive invisibility for dual-polarization channels and multifrequency channels is reported. Such strategy can intrinsically split the wavenumber of the scattering wave and therein is termed as wavenumber-splitting metasurface. For verification, two proof-of-concept examples are experimentally characterized. The first prototype manifests dual-polarized near-isotropic diffusive scattering immune from wide-angle incidences. The second demonstration exhibits bifunctionality of combined diffusive invisibility and vortex scattering in dual-polarization channels. In both cases, theoretical, numerical and experimental results agree well, illustrating a well-separated triple-band versatile scattering behavior. This approach addresses the fundamental issue of real invisibility under bistatic detection without complex optimization, thanks to the physical essence of numerous splitting wave vectors. Such strategy opens an upstream way to realize invisibility as well as holding the potentials for downstream applications such as stealth and camouflaging devices.

Keyword :

parabolic phase multiband invisibility wavenumber-splitting metasurfaces bifunctionality

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GB/T 7714 Xu, He-Xiu , Zhang, Lei , Kim, Yongjune et al. Wavenumber-Splitting Metasurfaces Achieve Multichannel Diffusive Invisibility [J]. | ADVANCED OPTICAL MATERIALS , 2018 , 6 (10) .
MLA Xu, He-Xiu et al. "Wavenumber-Splitting Metasurfaces Achieve Multichannel Diffusive Invisibility" . | ADVANCED OPTICAL MATERIALS 6 . 10 (2018) .
APA Xu, He-Xiu , Zhang, Lei , Kim, Yongjune , Wang, Guang-Ming , Zhang, Xiao-Kuan , Sun, Yunming et al. Wavenumber-Splitting Metasurfaces Achieve Multichannel Diffusive Invisibility . | ADVANCED OPTICAL MATERIALS , 2018 , 6 (10) .
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Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein EI SCIE Scopus CSCD
期刊论文 | 2018 , 27 (2) | CHINESE PHYSICS B
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Abstract :

Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule technologies and cryo-electron microscopy (cryo-EM), an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.

Keyword :

single-molecule method electron tomography bio-macromolecule cryo-electron microscopy

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GB/T 7714 Gou, Lu , Jin, Taoli , Chen, Shuyu et al. Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein [J]. | CHINESE PHYSICS B , 2018 , 27 (2) .
MLA Gou, Lu et al. "Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein" . | CHINESE PHYSICS B 27 . 2 (2018) .
APA Gou, Lu , Jin, Taoli , Chen, Shuyu , Li, Na , Hao, Dongxiao , Zhang, Shengli et al. Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein . | CHINESE PHYSICS B , 2018 , 27 (2) .
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Interface Colloidal Deposition of Nanoparticle Wire Structures EI SCIE Scopus
期刊论文 | 2018 , 35 (7) | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
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Inspired by natural dewetting phenomena, such as the coffee-ring effect, researchers are developing strategies for the controlled assembly of colloidal particles into functional nanoparticle conglomerates. Colloidal assembly techniques are regarded as green methods as they reduce or eliminate the use or generation of hazardous substances involved in other manufacturing modalities. This review discusses several recent developments in interface colloidal deposition for preparing nanoparticle wires and integrated nanoparticle wire arrays. Moreover, this review covers real applications of these structures for electric detection of chemical and biological molecules among other functions.

Keyword :

detection surface deposition nanoparticles

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GB/T 7714 Tian, Zhiqi , Crowe, Michael , Shao, Liqin et al. Interface Colloidal Deposition of Nanoparticle Wire Structures [J]. | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION , 2018 , 35 (7) .
MLA Tian, Zhiqi et al. "Interface Colloidal Deposition of Nanoparticle Wire Structures" . | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35 . 7 (2018) .
APA Tian, Zhiqi , Crowe, Michael , Shao, Liqin , Zhang, Peng , Zhang, Lei , Zhao, Qing et al. Interface Colloidal Deposition of Nanoparticle Wire Structures . | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION , 2018 , 35 (7) .
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Realization of Full Control of a Terahertz Wave Using Flexible Metasurfaces SCIE
期刊论文 | 2017 , 5 (24) | ADVANCED OPTICAL MATERIALS | IF: 7.43
WoS CC Cited Count: 4
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Compared with devices controlling microwave and visible light, there is a lack of functional devices for terahertz (THz) wave control. Moreover, the available THz elements are usually manufactured with bulk materials, in contrast to the trend of miniaturization and compact device requirements. Here, full control of both phase and amplitude is achieved experimentally and numerically at 0.14 THz, one of the atmospheric windows, by demonstrating the functionalities such as polarization conversion, metalenses and the generation of a non-diffraction Airy beam. Significantly, the metal structures are fabricated on a flexible substrate with a total thickness of approximate to 0.063 l via a standard flexible printed circuit technique. Taking into account the considerable manipulation efficiency and cost-efficient sample fabrication technique, the results show solid advances in the development of metasurfaces as a versatile platform for designing practical functional devices in the THz range.

Keyword :

polarization metasurfaces terahertz waves flexible materials optical materials

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GB/T 7714 Zhang, Lei , Zhang, Min , Liang, Huawei . Realization of Full Control of a Terahertz Wave Using Flexible Metasurfaces [J]. | ADVANCED OPTICAL MATERIALS , 2017 , 5 (24) .
MLA Zhang, Lei et al. "Realization of Full Control of a Terahertz Wave Using Flexible Metasurfaces" . | ADVANCED OPTICAL MATERIALS 5 . 24 (2017) .
APA Zhang, Lei , Zhang, Min , Liang, Huawei . Realization of Full Control of a Terahertz Wave Using Flexible Metasurfaces . | ADVANCED OPTICAL MATERIALS , 2017 , 5 (24) .
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Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation SCIE PubMed Scopus
期刊论文 | 2017 , 10 | FRONTIERS IN MOLECULAR NEUROSCIENCE | IF: 3.902
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Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensively studied. This review article expounds the neuronal membrane fusion processes, discusses the fundamental steps in all fusion reactions (membrane aggregation, membrane association, lipid rearrangement and lipid and content mixing) and the probable mechanism coupling to the delivery of neurotransmitters. Subsequently, this work summarizes the research on the fusion process in synaptic transmission, using electron microscopy (EM) and molecular simulation approaches. Finally, we propose the future outlook for more exciting applications of membrane fusion involved in synaptic transmission, with the aid of stochastic optical reconstruction microscopy (STORM), cryo-EM (cryo-EM), and molecular simulations.

Keyword :

membrane fusion neurotransmitter release machinery neurotransmission electron microscope molecular simulation

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GB/T 7714 Yang, Zhiwei , Gou, Lu , Chen, Shuyu et al. Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation [J]. | FRONTIERS IN MOLECULAR NEUROSCIENCE , 2017 , 10 .
MLA Yang, Zhiwei et al. "Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation" . | FRONTIERS IN MOLECULAR NEUROSCIENCE 10 (2017) .
APA Yang, Zhiwei , Gou, Lu , Chen, Shuyu , Li, Na , Zhang, Shengli , Zhang, Lei . Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation . | FRONTIERS IN MOLECULAR NEUROSCIENCE , 2017 , 10 .
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Unveiling the relationship between optical bistability and vacuum Rabi splitting SCIE Scopus
期刊论文 | 2017 , 117 (5) | EPL | IF: 1.834
WoS CC Cited Count: 1
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The relationship between optical bistability (OB) and vacuum Rabi splitting is experimentally demonstrated in an atomic ensemble confined in a three-mirror optical cavity. The vacuum-induced splitting and bright states can effectively affect the bistable behaviour by manipulating multiple parameters such as atomic density and detuning. Also, we observed another kind of "infinity"-shape OB by scanning the probe/cavity detuning. The study can make a contribution to better understand the OB and other dynamical behaviours in a composite atom-cavity system. Copyright (C) EPLA, 2017

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GB/T 7714 Zhang, Zhaoyang , Chen, Haixia , Zhang, Lei et al. Unveiling the relationship between optical bistability and vacuum Rabi splitting [J]. | EPL , 2017 , 117 (5) .
MLA Zhang, Zhaoyang et al. "Unveiling the relationship between optical bistability and vacuum Rabi splitting" . | EPL 117 . 5 (2017) .
APA Zhang, Zhaoyang , Chen, Haixia , Zhang, Lei , Zhang, Da , Li, Xinghua , Zhang, Yiqi et al. Unveiling the relationship between optical bistability and vacuum Rabi splitting . | EPL , 2017 , 117 (5) .
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Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light EI SCIE PubMed Scopus
期刊论文 | 2017 , 11 (9) , 9382-9389 | ACS NANO | IF: 13.709
WoS CC Cited Count: 20
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Abstract :

Efficient transmission-type meta-holograms have been demonstrated using high-index dielectric nanostructures based on Huygens principle. It is crucial that the geometry size of building blocks be judiciously optimized individually for spectral overlap of electric and magnetic dipoles. In contrast, reflection-type meta-holograms using the metal/insulator/metal scheme and geometric phase can be readily achieved with high efficiency and small thickness. Here, we demonstrate a general platform for design of dual magnetic resonance based meta-holograms based on the geometric phase using silicon nanostructures that are quarter wavelength thick for visible light. Significantly, the projected holographic image can be unambiguously observed without a receiving screen even under the illumination of natural light. Within the well-developed semiconductor industry, our ultrathin magnetic resonance-based meta-holograms may have promising applications in anticounterfeiting and information security.

Keyword :

magnetic resonance dielectric nanostructures image hologram metasurfaces

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GB/T 7714 Li, Zile , Kim, Inki , Zhang, Lei et al. Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light [J]. | ACS NANO , 2017 , 11 (9) : 9382-9389 .
MLA Li, Zile et al. "Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light" . | ACS NANO 11 . 9 (2017) : 9382-9389 .
APA Li, Zile , Kim, Inki , Zhang, Lei , Mehmood, Muhammad Q. , Anwar, Muhammad S. , Saleem, Murtaza et al. Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light . | ACS NANO , 2017 , 11 (9) , 9382-9389 .
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